Selected Publications

Dutta D., Ullah A., Bibi S., and Fliegel L. (2019) Functional Analysis of Conserved Transmembrane Charged Residues and a Yeast Specific Extracellular Loop of the Plasma Membrane Na +/H + Antiporter of Schizosaccharomyces pombe. Sci Rep. 9(1):6191.

Wong K.Y., McKay R., Liu Y., Towle K., Elloumi Y., Li X., Quan S., Dutta D., Sykes B.D., Fliegel L. (2018) Diverse residues of intracellular loop 5 of the Na+/H+ exchanger modulate proton sensing, expression, activity and targeting. Biochim Biophys Acta Biomembr. 1861(1):191-200.

Schammim Ray Amith, Jodi Marie Wilkinson, S. Baksh and Larry Fliegel (2015) The Na+/H+exchanger (NHE1) as a novel co-adjuvant target in paclitaxel therapy of triple-negative breast cancer cells. Oncotarget 6(2):1262-75. 25514463

Guissart, C., Li, X., Leheup, B., Drouot, N., Montaut-Verient, B., Raffo, E., Jonveaux, P., Roux, A. F., Claustres, M., Fliegel, L., and Koenig, M. (2015) Mutation of SLC9A1, encoding the major Na+/H+ exchanger, causes ataxia-deafness Lichtenstein-Knorr syndrome. Hum Mol Genet 24, 463-470. 25205112.

Ullah, A., Kemp, G., Lee, B., Alves, C., Young, H., Sykes, B. D., and Fliegel, L. (2013) Structural and functional analysis of transmembrane segment IV of the salt tolerance protein Sod2. J Biol Chem 288, 24609-24624.   23836910

Li, X., Prins, D., Michalak, M., and Fliegel, L. (2013) Calmodulin-dependent binding to the NHE1 cytosolic tail mediates activation of the Na+/H+ exchanger by Ca2+ and endothelin. Am J Physiol Cell Physiol 305, C1161-1169.   24088894

Karki, P., Li, X., Schrama, D., and Fliegel, L. (2011) B-Raf associates with and activates the NHE1 isoform of the Na+/H+ exchanger. J Biol Chem 286, 13096-13105.   21345796

E. Coccaro, P. Karki, C. Cojocaru and L. Fliegel (2009) Acute acidosis and phenylephrine activate neonatal rat cardiomyocyte Na+/H+ exchanger through phosphorylation of amino acids Ser770 and Ser771. Am. J. Physiol. (Heart) 297(2):H846-H858

B. L. Lee, X. Li, Y. Liu, B. D. Sykes and L. Fliegel (2009) Structural and functional analysis of TM XI of the NHE1 isoform of the Na+/H+ exchanger. J. Biol. Chem. 284:11546-11556.

T. Reddy, J. Ding, X. Li, B.D. Sykes, J.K. Rainey and L. Fliegel. (2008) Structural and functional characterization of TM IX of the NHE1 isoform of the Na+/H+ exchanger In J. Biol. Chem. 283(32): 22018-22030