Publications

The na+/H+ exchanger in metastasis 

Aberrant regulation of the Na+/H+ exchanger exacerbates damage to the myocardium in heart disease 

Na+/H+ exchange in the tumour microenvironment: Does NHE1 drive breast cancer carcinogenesis?

Regulation of the Na+/H+ exchanger by rat Myocardial Protein Kinases: Phosphorylation by MAP-Kinase and p90RSK 

Molecular analysis of residues essential for the function of the Na+/H+ exchanger of fission yeast, Schizosaccharomyces pombe 

Structure of the rabbit fast-twitch skeletal muscle calsequestrin gene 

Molecular cloning of the high affinity calcium binding protein (calreticulin) of skeletal muscle sarcoplasmic reticulum 

Isolation and characterization of calcium binding glycoproteins of cardiac sarcolemmal vesicles 

Molecular cloning of cDNA encoding a 55-kDa multifunctional thyroid hormone binding protein of skeletal muscle sarcoplasmic reticulum 

Activation of the Na+/H+ exchanger promoter by the transcription factor AP-2 

Specific Activation of the Na+/H+ exchanger gene during neuronal differentiation of embryonal carcinoma cells 

Ectopic expression of human and feline CD9 in a Human B cell line confers ß1 integrin-dependent motility on fibronectin and laminin substrates and enhanced tyrosine phosphorylation 

Regulation of Na+/H+ Exchanger Gene Expression: Role of a poly T rich region in regulation of expression of the NHE1 promoter 

The Na+/H+ exchanger potentiates growth and retinoic acid induced differentiation of embryonal carcinoma cells 

Protein Kinase Mediated Regulation of the Na+/H+ Exchanger in the Rat Myocardium by MAP-Kinase-dependent Pathways 

COUP-TF1 antagonizes Nkx25-mediated activation of the calreticulin gene during cardiac development 

Activation of Na+/H+ exchanger-directed protein kinases in the ischemic and ischemic-reperfused rat myocardium 

Thyroid hormone receptor alpha(1) regulates expression of the na+/H+ exchanger (NHE1) 

Carbonic anhydrase II binds to and enhances activity of the na+/H+ exchanger 

 
Structural and functional characterization of transmembrane segment VII of the na+/H+ exchanger isoform 1 

Mitogen-activated protein kinase-dependent activation of the na+/H+ exchanger is mediated through phosphorylation of amino acids ser(770) and ser(771)

Dimeric structure of human na+/H+ exchanger isoform 1 overproduced in saccharomyces cerevisiae

Structural and functional characterization of transmembrane segment IX of the NHE1 isoform of the na(+)/H(+) exchanger 

Structural and functional analysis of transmembrane XI of the NHE1 isoform of the na+/H+ exchanger 

Structural and functional analysis of transmembrane segment VI of the NHE1 isoform of the na+/H+ exchanger 

B-raf associates with and activates the NHE1 isoform of the na+/H+ exchanger

Structural and functional analysis of transmembrane segment IV of the salt tolerance protein Sod2 

Trophic factor withdrawal: p38 mitogen-activated protein kinase activates NHE1, which induces intracellular alkalinization 

Effects of extracellular pH on internal pH in cell cycle defective Schizosaccharomyces pombe 

The na+/H+ exchanger (NHE1) as a novel co-adjuvant target in paclitaxel therapy of triple-negative breast cancer cells 

Na+/H+ exchanger NHE1 regulation modulates metastatic potential and epithelial-mesenchymal transition of triple-negative breast cancer cells 

A novel human mutation in the SLC9A1 gene results in abolition of na+/H+ exchanger activity 

Na+/H+ exchanger isoform 1-induced osteopontin expression facilitates cardiomyocyte hypertrophy 

Stop codon polymorphisms in the human SLC9A1 gene disrupt or compromise na+/H+ exchanger function 

Amino acid sequence of fast-twitch skeletal muscle calsequestrin 

Transmembrane segment XI of the na+/H+ antiporter of S. pombe is a critical part of the ion translocation pore
Our Research

Our laboratory studies the regulation of intracellular pH and the removal of excess intracellular acid. In mammalian tissues the main protein responsible for this is the Na+/H+ exchanger.

Who We Are

Larry Fliegel, Principal Investigator

Contact Us

Dr. Larry Fliegel
Professor
Associate Chair, Department of Biochemistry

Ph.D., University of Calgary

Department of Biochemistry
Faculty of Medicine & Dentistry
University of Alberta
347 Medical Sciences Building
Edmonton, Alberta, Canada  T6G 2H7

Tel: 780.492.1848
Lab Tel: 780.492.1847
Fax: 780.492.0886

Email Dr. Fliegel

Data Deposits

© 2018 Department of Biochemistry University of Alberta